Griseofulvin: A Comprehensive Review of its Antifungal, Pharmacological, and Clinical Implications

Document Type : Scientific review

Authors

1 Department of analytical pharmaceutical chemistry, Faculty of Pharmacy, Alsalam University, Kafr alzayat, Algharbia 31611, Egypt 3 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alsalam University, Kafr alzayat, Algharbia

2 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alsalam University, Kafr alzayat, Algharbia 31611, Egypt

Abstract

Griseofulvin, a natural antifungal agent derived from Penicillium species, has been widely used for the treatment of dermatophytic infections. Its mechanism of action involves binding to tubulin, disrupting microtubule function, and inhibiting fungal mitosis. Despite its limited spectrum, griseofulvin remains a cornerstone therapy for tinea infections due to its efficacy and safety profile. This review provides a comprehensive analysis of its pharmacokinetics, clinical applications, adverse effects, and drug interactions. Beyond its antifungal role, emerging evidence suggests potential applications in oncology and antiviral therapy, particularly in inhibiting tumor cell division and suppressing hepatitis C virus replication. However, its use is associated with hepatotoxicity, hypersensitivity reactions, and teratogenic effects, necessitating cautious administration in specific patient populations. The review will further explores advances in drug formulations aimed at improving bioavailability and therapeutic outcomes. By consolidating current knowledge, this article aims to enhance the understanding of Griseofulvin’s clinical implications and its evolving therapeutic landscape.

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